What CD4 count indicates the need for prophylaxis against Pneumocystis pneumonia?

The indication for prophylaxis against Pneumocystis pneumonia (PCP) in individuals with HIV is primarily based on the CD4 cell count. When the CD4 count falls to 200 cells/mm³ or below, it signifies an increased risk for opportunistic infections, including PCP. Initiating prophylaxis at this threshold helps prevent the development of severe, and potentially life-threatening infections in immunocompromised patients.

Regular monitoring and preventive measures are critical in managing patient health as CD4 counts can fluctuate. Thus, identifying the critical cut-off at 200 cells/mm³ is essential in clinical practice to ensure timely intervention when the immune system is significantly weakened. This understanding is crucial for healthcare providers in their role of preventing complications in patients with advanced HIV/AIDS.