What is a common side effect of prolonged steroid use aside from osteoporosis?

Cushing's Syndrome is a recognized condition that arises from prolonged exposure to corticosteroids, which can occur with long-term use of steroid medications. This syndrome is characterized by a set of symptoms including weight gain, especially in the trunk and face (often referred to as "moon facies"), skin changes, hypertension, diabetes mellitus, and suppression of the immune system.

Corticosteroids mimic the effects of cortisol, a hormone produced by the adrenal glands, and their excessive presence can lead to these alterations in metabolism and overall physiology, contributing to the development of Cushing's Syndrome. Recognizing this side effect is crucial for managing patients on long-term steroid therapy, as early intervention can help mitigate some of the negative outcomes associated with corticoid-induced changes.

Other potential side effects, such as hypertension, hyperglycemia, or fluid retention, might be considered but are typically part of the broader spectrum of issues associated with prolonged steroid use rather than a distinct syndrome like Cushing's. Thus, the identification of Cushing's Syndrome as a common side effect highlights the significant systemic impact of long-term corticosteroid therapy.