What is a well-known side effect of the medication Indinavir?

Indinavir is an antiretroviral medication used to treat HIV infection, and one of its notable side effects is kidney stone formation. This is due to the drug's tendency to precipitate in the urine, which can lead to crystalluria and subsequently kidney stones. The mechanism relates to indinavir's solubility, particularly at acidic urine pH levels, contributing to this renal side effect.

While other side effects are associated with antiretroviral therapies, they are not specifically prominent in the context of indinavir. For example, liver toxicity is a concern with many medications but is not uniquely associated with indinavir. Osteoporosis and peripheral neuropathy may be relevant in the broader spectrum of HIV treatments but are not commonly linked to indinavir. Hence, the specific connection between indinavir and the formation of kidney stones makes this answer the most appropriate.