What is the function of ACE inhibitors in patients with CKD?

The primary function of ACE inhibitors in patients with chronic kidney disease (CKD) is to decrease hypertension. In patients with CKD, hypertension is a common complication that can exacerbate kidney damage and lead to the progression of the disease. By inhibiting the angiotensin-converting enzyme (ACE), these medications lower levels of angiotensin II, a potent vasoconstrictor that raises blood pressure.

Lowering blood pressure through the use of ACE inhibitors not only helps manage hypertension but also provides renal protective effects. These medications reduce intraglomerular pressure by dilating the efferent arterioles, which helps to preserve kidney function and slow the progression of CKD. This combination of blood pressure control and renal protection is particularly beneficial for patients with diabetes or proteinuria, as it reduces the risk of further kidney damage.

The other options do not accurately describe the primary function of ACE inhibitors. They can increase potassium levels, which is a potential side effect but not a therapeutic function, and they do not affect intra-abdominal pressure or promote inflammation in a manner that would be beneficial in CKD management.