What is the main clinical presentation associated with aspirin exacerbated respiratory disease?

Aspirin exacerbated respiratory disease is primarily characterized by a distinct triad of asthma, nasal polyps, and aspirin sensitivity. In individuals with this condition, the ingestion of aspirin or other nonsteroidal anti-inflammatory medications can lead to severe respiratory reactions, including exacerbation of asthma symptoms. The presence of nasal polyps is significant as they often co-occur with asthma and are an important clinical marker of this disease.

Individuals with this triad may experience worsening breathing difficulty, nasal congestion, and other respiratory distress symptoms following aspirin exposure. Understanding this triad is essential in diagnosing and managing patients who exhibit these symptoms, especially in the context of chronic asthma and nasal symptoms. Thus, identifying the combination of asthma and nasal polyps is central to recognizing aspirin exacerbated respiratory disease in clinical practice.