What is the primary treatment recommended for Pemphigus Vulgaris?

In the management of Pemphigus Vulgaris, the primary treatment commonly recommended is oral corticosteroids. This condition is characterized by blistering of the skin and mucous membranes due to an autoimmune response where the body produces antibodies against desmosomes, which are vital for cell adhesion in the epidermis. The use of oral corticosteroids helps to quickly suppress the immune response, reducing inflammation and facilitating the healing of blistered lesions.

While topical corticosteroids and immunosuppressants can be used as adjunct therapies or in specific cases, they are not considered the first line of treatment due to their slower onset of action or specific indications. Biologic therapies, although emerging as options in more resistant cases, are not yet standard first-line treatments for Pemphigus Vulgaris. Thus, oral corticosteroids play a pivotal role in quickly managing this serious condition and preventing complications.