What is the recommended treatment for Typhoid fever?

The recommended treatment for Typhoid fever is fluoroquinolone. This class of antibiotics is effective against Salmonella typhi, the bacterium responsible for Typhoid fever. Over the years, fluoroquinolones have demonstrated good bioavailability and tissue penetration, which enhances their efficacy in treating this infection. They also possess a relatively rapid onset of action, making them suitable for managing acute cases of Typhoid fever.

In the context of antibiotic resistance, particularly with the increasing prevalence of multidrug-resistant Salmonella strains, fluoroquinolones have become a go-to option in many parts of the world. It is also important to consider the patient's specific geographic exposure and any local resistance patterns before selecting a treatment.

Other antibiotics, like ampicillin, vancomycin, and metronidazole, are not first-line treatments for Typhoid fever due to either their limited efficacy against Salmonella typhi or recommendations based on susceptibility patterns. For example, ampicillin has been less effective due to rising resistance, while vancomycin is primarily used for Gram-positive infections and not indicated for Salmonella. Metronidazole is mainly used to treat anaerobic infections and protozoal diseases, which makes it inappropriate for