What signifies the complication of right-sided heart lesions in Carcinoid Syndrome?

In Carcinoid Syndrome, right-sided heart lesions are particularly significant due to the disease's underlying pathophysiology, which involves the excessive secretion of serotonin and other vasoactive substances from neuroendocrine tumors. The correct answer focuses on heart valve involvement, which is a characteristic complication associated with Carcinoid Syndrome.

The lesions typically affect the right heart structures, including the tricuspid valve and the pulmonary valve, leading to fibrosis and dysfunction. The elevated levels of serotonin, which often come from the tumor's secretion, result in a fibrotic reaction that predominantly affects the right side of the heart. This can lead to manifestations such as tricuspid regurgitation and pulmonary stenosis, compromising the normal functioning of the heart and contributing to symptoms like heart failure and systemic venous congestion.

While other options may involve some aspects linked to heart and lung function, they do not capture the specificity of the heart valve pathology seen in patients with Carcinoid Syndrome as clearly as heart valve involvement does.