What skin symptom is commonly associated with Glucagonoma?

Glucagonoma, a rare neuroendocrine tumor arising from the alpha cells of the pancreas, is characteristically associated with necrolytic migratory erythema. This skin condition is distinguished by erythematous plaques, often with a central crust or erosion that migrates over time, typically affecting areas such as the groin, buttocks, abdomen, and legs. It is a key cutaneous manifestation of glucagonoma and is believed to be related to the excess glucagon secreted by the tumor, which alters amino acid metabolism and leads to skin changes.

This symptom serves as an important clinical clue, as patients often present with weight loss, diabetes, and other metabolic symptoms in addition to the skin lesions. Early recognition of necrolytic migratory erythema can prompt appropriate diagnostic investigations for glucagonoma, assisting in timely management of this malignancy. The other options listed do not have the strong association with glucagonoma that necrolytic migratory erythema does, making it the most relevant choice.