What specific antibodies are associated with Pemphigus Vulgaris?

Pemphigus vulgaris is an autoimmune blistering disorder characterized by the presence of antibodies that target specific components of the skin. In this condition, the primary antibodies are directed against desmosomes, which are cell structures that function to adhere adjacent keratinocytes to each other. The main target in pemphigus vulgaris is desmoglein, a protein found in desmosomes that plays a critical role in maintaining the integrity of the epidermal barrier.

When antibodies are formed against desmogleins, this leads to a disruption of the desmosomal connections between keratinocytes, resulting in acantholysis (loss of cohesion between the cells) and the formation of blisters in the skin and mucous membranes. This pathological process explains the clinical manifestations of pemphigus vulgaris, including painful blisters and erosions.

The other answer choices refer to elements that are not central to the pathology of pemphigus vulgaris. Hemidesmosomes are structures that anchor the epidermis to the basement membrane, and while antibodies against hemidesmosomes are seen in conditions like pemphigoid, they are not involved in pemphigus vulgaris. Antibodies against collagen pertain to different autoimmune conditions, such as s