What type of immunoglobulin is associated with warm agglutinin disease?

Warm agglutinin disease is primarily associated with IgG immunoglobulins. This condition is characterized by the production of autoantibodies that react against red blood cells at body temperature, leading to their agglutination and subsequent hemolysis. In warm agglutinin disease, these IgG antibodies often bind to erythrocytes, marking them for destruction by macrophages in the spleen.

IgM, on the other hand, is typically associated with cold agglutinin disease, where antibodies react at lower temperatures. IgA and IgE are involved in different immune responses and are not commonly implicated in warm agglutinin disease. Therefore, IgG stands out as the key immunoglobulin in this context, highlighting its role in this particular type of autoimmune hemolytic anemia.