Which cells are typically observed in a classic CBC finding for hemolytic anemias?

In the context of hemolytic anemias, schistocytes are commonly identified in a complete blood count (CBC) due to the destruction of red blood cells (RBCs). Schistocytes are fragmented red blood cells that result from mechanical stress or injury, often associated with conditions that cause microangiopathic hemolytic anemia.

The presence of schistocytes signifies that the blood cells are being damaged as they pass through small blood vessels, which is a hallmark of various hemolytic processes. This fragmentation occurs due to processes involving intravascular hemolysis, such as thrombotic thrombocytopenic purpura (TTP) or disseminated intravascular coagulation (DIC).

In contrast, while polychromatophils can be seen in hemolytic anemias as a response to increased reticulocyte production, they are not as definitive as schistocytes for diagnosing the type of anemia. Target cells, which may appear in conditions like liver disease or thalassemia, are not specific for hemolysis. Lastly, myeloblasts represent immature cells typically found in acute leukemias and do not relate to hemolytic anemia.

Therefore, schistocytes stand out as