Which condition is characterized by an opening snap with diastolic rumble at the left 4th intercostal space?

The presence of an opening snap followed by a diastolic rumble is indicative of mitral stenosis, a condition resulting from narrowing of the mitral valve, which impedes blood flow from the left atrium to the left ventricle during diastole. This contributes to an increase in left atrial pressure, leading to characteristic heart sounds.

The opening snap is heard due to the abrupt halt of the mitral valve leaflets when they are forced open by the increased left atrial pressure. This is followed by a low-pitched diastolic rumble caused by the turbulent blood flow across the narrowed valve. The most common location for auscultation of these sounds is at the left 4th intercostal space, near the sternum, which aligns with the position of the heart chambers.

Tricuspid stenosis would typically present with different auscultation findings, primarily affecting the right side of the heart. Conditions such as aortic regurgitation and pulmonic regurgitation also have distinct auscultation characteristics and would not display an opening snap associated with diastolic rumble in the same manner as mitral stenosis.