Which tetracycline can cause nephrogenic diabetes insipidus?

Demeclocycline is known to cause nephrogenic diabetes insipidus due to its interference with the action of antidiuretic hormone (ADH) in the kidneys. It acts as a partial antagonist at the vasopressin receptor, which is critical for the reabsorption of water in the renal system. As a result, the kidneys become less responsive to ADH, leading to increased urination and the symptoms associated with diabetes insipidus.

This condition highlights a specific side effect that is more prominently associated with demeclocycline, making it distinct among the tetracyclines. Other tetracyclines, such as minocycline, oxytetracycline, and tigecycline, do not share this particular adverse effect to the same degree, primarily focusing their therapeutic use on antibacterial activity rather than impacting renal handling of water in the same manner.