Which treatment options are indicated for C. Diff infection?

The treatment options for Clostridium difficile (C. diff) infection primarily include oral vancomycin and metronidazole. These are considered first-line therapies for managing C. diff infections, particularly for mild to moderate cases.

Oral vancomycin is often preferred for more severe cases or recurrent infections due to its effectiveness against the C. diff bacteria. Metronidazole was traditionally used as an alternative, especially in mild to moderate cases, although current guidelines often recommend vancomycin as the primary treatment.

In contrast, the other options provided are not indicated for C. diff infections. Amoxicillin and ciprofloxacin are antibiotics that do not target C. diff and can even contribute to the development of such infections by disrupting normal gut flora. Trimethoprim/sulfamethoxazole is another antibiotic not used for C. diff treatment. It is more aligned with treating urinary tract infections and certain respiratory infections. Lastly, while fidaxomicin is a newer agent effective for C. diff, loperamide is an antidiarrheal medication that is contraindicated in cases of infectious diarrhea, including C. diff, as it may worsen the disease by slowing down the clearance of the bacteria from the intestines.