Which two treatments are recommended for Acute Interstitial Nephritis?

The recommended treatment for Acute Interstitial Nephritis (AIN) primarily focuses on addressing the underlying cause, which often involves stopping any offending medications that may have triggered the condition. In many cases, this is sufficient for the resolution of the symptoms. However, if the inflammation persists or if there is significant renal impairment, the addition of corticosteroids can be beneficial in reducing the immune-mediated inflammatory response. Steroids help to modulate the immune system, leading to decreased inflammation in the interstitial tissue of the kidneys.

The choice to stop the offending drug is critical because many cases of AIN are drug-induced, and ceasing the medication often results in improvement. Steroids may be necessary in situations where rapid improvement is essential or when there are severe symptoms.

While diuretics can be used for managing fluid overload in certain renal conditions, they do not address the underlying inflammation present in AIN. Similarly, antibiotics might be indicated if there is a secondary infection, but they do not directly treat AIN itself. Dialysis is typically reserved for acute renal failure that does not resolve with conservative measures and is not a primary treatment for AIN.

In summary, the combination of stopping the causative agent and using steroids is effective in managing Acute Interstitial Ne